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Progress has been made over the last 50 years by using intensive chemotherapy regimens
(combined with surgery and/or radiotherapy in solid tumours). This includes improved
outcomes in some cancers with poor prognosis such as high-risk neuroblastoma (40%
survival with highly intensive chemotherapy regimens including immunotherapy) and
acute myeloid leukaemia (60% survival with intensive chemotherapy and allogeneic
hematopoietic stem cell transplantation).
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Patient survival has plateaued over the last five years or more for difficult-to-treat diseases,
which calls for innovative treatments with new mechanisms of action to control resilient
and resistant diseases.
There has been little progress regarding difficult-to-treat diseases during the
last five years
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A EUROPEAN CANCER PLAN FOR CHILDREN AND ADOLESCENTS
Credit Czech Working Group for Paediatric Oncology, Czech Republic
“Children and adolescents with cancer
need to be treated within clinical trials and benefit
from all the facilities required by standard of care.”
(Marianne Naafs-Wilstra, parent advocate, VOKK,
The Netherlands)